Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_1151
Protein Name
Aquaporin Z
Gene Name
aqpZ; VV2404
Organism
Vibrio vulnificus (strain YJ016)
Length
231 amino acids
AlphaFoldDB
AF-Q7MIV9-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MNKYLAELFGTFWLVLGGCGSAVLAAAFPDVGIGLLGVSLAFGLTVLTMAFAIGHISGCHLNPAVTIGLWAGGRFEAKEIVPYILAQVIGGVIAGGVLYTIASGQMGFDATSSGFASNGYGEHSPGGYSLTSALVTEIVMAMMFLLVILGATDQRAPQGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGVALYVGDWATAQLWLFWVAPILGALLGAVAYKLISGSNKD
PDB Structures
Ligand Binding
Binding Site
SITE 19: "Involved in tetramerization or stability of the tetramer"; SITE 42: "Selectivity filter"; SITE 173: "Selectivity filter"; SITE 182: "Selectivity filter"; SITE 188: "Selectivity filter"
Disease
Location
DOI ID
10.1101/gr.1295503
RefSeq
WP_011150869.1